Ensemble learning with GSGP

Dissertation presented as the partial requirement for obtaining a Master's degree in Data Science and Advanced AnalyticsThe purpose of this thesis is to conduct comparative research between Genetic Programming (GP) and Geometric Semantic Genetic Programming (GSGP), with different initialization (RHH and EDDA) and selection (Tournament and Epsilon-Lexicase) strategies, in the context of a model-ensemble in order to solve regression optimization problems. A model-ensemble is a combination of base learners used in different ways to solve a problem. The most common ensemble is the mean, where the base learners are combined in a linear fashion, all having the same weights. However, more sophisticated ensembles can be inferred, providing higher generalization ability. GSGP is a variant of GP using different genetic operators. No previous research has been conducted to see if GSGP can perform better than GP in model-ensemble learning. The evolutionary process of GP and GSGP should allow us to learn about the strength of each of those base models to provide a more accurate and robust solution. The base-models used for this analysis were Linear Regression, Random Forest, Support Vector Machine and Multi-Layer Perceptron. This analysis has been conducted using 7 different optimization problems and 4 real-world datasets. The results obtained with GSGP are statistically significantly better than GP for most cases.O objetivo desta tese é realizar pesquisas comparativas entre Programação Genética (GP) e Programação Genética Semântica Geométrica (GSGP), com diferentes estratégias de inicialização (RHH e EDDA) e seleção (Tournament e Epsilon-Lexicase), no contexto de um conjunto de modelos, a fim de resolver problemas de otimização de regressão. Um conjunto de modelos é uma combinação de alunos de base usados de diferentes maneiras para resolver um problema. O conjunto mais comum é a média, na qual os alunos da base são combinados de maneira linear, todos com os mesmos pesos. No entanto, conjuntos mais sofisticados podem ser inferidos, proporcionando maior capacidade de generalização. O GSGP é uma variante do GP usando diferentes operadores genéticos. Nenhuma pesquisa anterior foi realizada para verificar se o GSGP pode ter um desempenho melhor que o GP no aprendizado de modelos. O processo evolutivo do GP e GSGP deve permitir-nos aprender sobre a força de cada um desses modelos de base para fornecer uma solução mais precisa e robusta. Os modelos de base utilizados para esta análise foram: Regressão Linear, Floresta Aleatória, Máquina de Vetor de Suporte e Perceptron de Camadas Múltiplas. Essa análise foi realizada usando 7 problemas de otimização diferentes e 4 conjuntos de dados do mundo real. Os resultados obtidos com o GSGP são estatisticamente significativamente melhores que o GP na maioria dos casos

Late Cenozoic metamorphic evolution and exhumation of Taiwan

The Taiwan mountain belt is composed of a Cenozoic slate belt (Hsuehshan Range units, HR, and Backbone Slates, BS) and of accreted polymetamorphic basement rocks (Tananao Complex, TC). Ongoing crustal shortening has resulted from the collision between the Chinese continental margin and the Luzon volcanic arc, which initiated ~6.5 Ma ago. The grade and age of metamorphism and exhumation are a key record of the development of the orogenic wedge. Because the Taiwan mountain belt is mostly composed by accreted sediments lacking metamorphic index minerals, quantitative constraints on metamorphism are sparse. By contrast, these rocks are rich in carbonaceaous material (CM) and are therefore particularly appropriate for RSCM (Raman Spectroscopy of CM) thermometry. We apply this technique in addition to (U-Th)/He thermochronology on detrital zircons to assess peak metamorphic temperatures (T) and the late exhumational history respectively, along different transects in central and southern Taiwan. In the case of the HR units, we find evidence for high metamorphic T of at least 340°–350°C and locally up to 475°C, and for relative rapid exhumation with zircon (U-Th)/He ages in the range of 1.5–2 Ma. Farther east, the BS were only slightly metamorphosed (T < 330 °C), and zircons are not reset for (U-Th)/He. From the eastern BS to the inner TC schists, T gradually increases from ~350°C up to ~500°C following an inverted metamorphic gradient. Available geochronological constraints and the continuous thermal gradient from the BS to the basement rocks of the TC suggest that the high RSCM T of the TC were most probably acquired during the last orogeny, and were not inherited from a previous thermal event. Zircons yield (U-Th)/He ages of ~0.5–1.2 Ma. Peak metamorphic T and the timing of exhumation do not show along-strike variations over the TC in the studied area. In contrast, exhumation is laterally diachronous and decreases southward in the case of the HR units. In particular, our data imply that the HR units have been exhumed by a minimum of 15 km over the last few Ma. In the case of the BS, they show far less cumulated exhumation and much slower cooling rates. We propose that most of the deformation and exhumation of the Taiwan mountain belt is sustained through two underplating windows located beneath the Hsuehshan Range and the TC. Our data show significant departures from the predictions of the prevailing model in Taiwan, which assumes a homogeneous critical wedge with dominant frontal accretion. Our study sheds new light on how the mountain belt has grown as a possible result of underplating mostly

Mountain building in Taiwan: A thermokinematic model

The Taiwan mountain belt is classically viewed as a case example of a critical wedge growing essentially by frontal accretion and therefore submitted to distributed shortening. However, a number of observations call for a significant contribution of underplating to the growth of the orogenic wedge. We propose here a new thermokinematic model of the Taiwan mountain belt reconciling existing kinematic, thermometric and thermochronological constraints. In this model, shortening across the orogen is absorbed by slip on the most frontal faults of the foothills. Crustal thickening and exhumation are sustained by underplating beneath the easternmost portion of the wedge (Tananao Complex, TC), where the uplift rate is estimated to ~6.3 mm a^(−1), and beneath the westernmost internal region of the orogen (Hsueshan Range units, HR), where the uplift rate is estimated to ~4.2 mm a^(−1). Our model suggests that the TC units experienced a synchronous evolution along strike despite the southward propagation of the collision. It also indicates that they have reached a steady state in terms of cooling ages but not in terms of peak metamorphic temperatures. Exhumation of the HR units increases northward but has not yet reached an exhumational steady state. Presently, frontal accretion accounts for less than ~10% of the incoming flux of material into the orogen, although there is indication that it was contributing substantially more (~80%) before 4 Ma. The incoming flux of material accreted beneath the TC significantly increased 1.5 Ma ago. Our results also suggest that the flux of material accreted to the orogen corresponds to the top ~7 km of the upper crust of the underthrust Chinese margin. This indicates that a significant amount (~76%) of the underthrust material has been subducted into the mantle, probably because of the increase in density associated with metamorphism. We also show that the density distribution resulting from metamorphism within the orogenic wedge explains well the topography and the gravity field. By combining available geological data on the thermal and kinematic evolution of the wedge, our study sheds new light onto mountain building processes in Taiwan and allows for reappraising the initial structural architecture of the passive margin

Amphiphilic block copolymers enhance the cellular uptake of DNA molecules through a facilitated plasma membrane transport

Amphiphilic block copolymers have been developed recently for their efficient, in vivo transfection activities in various tissues. Surprisingly, we observed that amphiphilic block copolymers such as Lutrol® do not allow the transfection of cultured cells in vitro, suggesting that the cell environment is strongly involved in their mechanism of action. In an in vitro model mimicking the in vivo situation we showed that pre-treatment of cells with Lutrol®, prior to their incubation with DNA molecules in the presence of cationic lipid, resulted in higher levels of reporter gene expression. We also showed that this improvement in transfection efficiency associated with the presence of Lutrol® was observed irrespective of the plasmid promoter. Considering the various steps that could be improved by Lutrol®, we concluded that the nucleic acids molecule internalization step is the most important barrier affected by Lutrol®. Microscopic examination of transfected cells pre-treated with Lutrol® confirmed that more plasmid DNA copies were internalized. Absence of cationic lipid did not impair Lutrol®-mediated DNA internalization, but critically impaired endosomal escape. Our results strongly suggest that in vivo, Lutrol® improves transfection by a physicochemical mechanism, leading to cellular uptake enhancement through a direct delivery into the cytoplasm, and not via endosomal pathways

Linkage and association of haplotypes at the APOA1/C3/A4/A5 genecluster to familial combined hyperlipidemia

Combined hyperlipidemia (CHL) is a common disorder of lipidmetabolism that leads to an increased risk of cardiovascular disease. Thelipid profile of CHL is characterised by high levels of atherogeniclipoproteins and low levels of high-density-lipoprotein-cholesterol.Apolipoprotein (APO) A5 is a newly discovered gene involved in lipidmetabolism located within 30kbp of the APOA1/C3/A4 gene cluster. Previousstudies have indicated that sequence variants in this cluster areassociated with increased plasma lipid levels. To establish whethervariation at the APOA5 gene contributes to the transmission of CHL, weperformed linkage and linkage disequilibrium (LD) tests on a large cohortof families (n=128) with familial CHL (FCHL). The linkage data producedevidence for linkage of the APOA1/C3/A4/A5 genomic interval to FCHL (NPL= 1.7, P = 0.042). The LD studies substantiated these data. Twoindependent rare alleles, APOA5c.56G and APOC3c.386G of this gene clusterwere over-transmitted in FCHL (P = 0.004 and 0.007, respectively), andthis was associated with a reduced transmission of the most commonAPOA1/C3/A4/A5 haplotype (frequency 0.4425) to affected subjects (P =0.013). The APOA5c.56G allele was associated with increased plasmatriglyceride levels in FCHL probands, whereas the second, andindependent, APOC3c.386G allele was associated with increased plasmatriglyceride levels in FCHL pedigree founders. Thus, this allele (or anallele in LD) may mark a quantitative trait associated with FCHL, as wellas representing a disease susceptibility locus for the condition. Thisstudy establishes that sequence variation in the APOA1/C3/A4/A5 genecluster contributes to the transmission of FCHL in a substantialproportion of affected families, and that these sequence variants mayalso contribute to the lipid abnormalities of the metabolic syndrome,which is present in up to 40 percent of persons with cardiovasculardisease

IXPE and XMM-Newton observations of the Soft Gamma Repeater SGR 1806-20

Recent observations with the Imaging X-ray Polarimetry Explorer (IXPE) of two anomalous X-ray pulsars provided evidence that X-ray emission from magnetar sources is strongly polarized. Here we report on the joint IXPE and XMM-Newton observations of the soft {\gamma}-repeater SGR 1806-20. The spectral and timing properties of SGR 1806-20 derived from XMM-Newton data are in broad agreement with previous measurements; however, we found the source at an all-time-low persistent flux level. No significant polarization was measured apart from the 4-5 keV energy range, where a probable detection with PD=31.6\pm 10.5% and PA=-17.6\pm 15 deg was obtained. The resulting polarization signal, together with the upper limits we derive at lower and higher energies 2-4 and 5-8 keV, respectively) is compatible with a picture in which thermal radiation from the condensed star surface is reprocessed by resonant Compton scattering in the magnetosphere, similar to what proposed for the bright magnetar 4U 0142+61.Comment: 11 pages, 3 figures, accepted for publication in Ap

Auditory and visual motion processing in hMT+/V5: preliminary results at 7T fMRI.

The ability of the brain to integrate motion information originating from separate sensory modalities is fundamental to efficiently interact with our dynamic environment. The human occipito-temporal region hMT+/V5 is known to be highly specialized to process visual motion directions. In addition to its role in processing the dominant visual information, it was recently suggested that this region may also engage in crossmodal motion processing from the auditory modality. How multisensory information is represented in this region remains however poorly understood. To further investigate the multisensory nature of hMT+/V5, we characterized single-subject activity with ultra-high field (UHF) fMRI when participants processed horizontal and vertical motion stimuli delivered through vision, audition, or a combination of both modalities simultaneously. Our preliminary results confirmed that in addition to a robust selectivity for visual motion, portion of hMT+/V5 selectively responds to moving sounds. We are now further characterizing the brain activity in the cortical depths using UHF fMRI combined with vascular space occupancy (VASO) recording at high spatial resolution (.75mm isotropic). We hypothesize that hMT+/V5 might encode auditory and visual motion information in separate cortical layers, reflecting the feed-forward versus feed-back nature of how sensory information flows into those regions. This project will shed new lights on how crossmodal information is represented across the depth of the cortical layers of motion selective human brain areas

Late Cenozoic metamorphism and mountain building in Taiwan: A review

International audienc